Central nervous system (CNS) and peripheral nervous system (PNS) disorders in HIV-infected individuals may result from opportunistic infections, neoplasms and processes that appear to be primary effects of human immunodeficieny virus (HIV) itself. The nervous system may also be damaged as a result of the toxic effects of various treatments. Indeed, the majority of AIDS patients will eventually manifest one or more of these neurological conditions.
Primary Effects of HIV on the CNS
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REFERENCES:
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Relationship to clinical and neurological status. Ann Neurol 29(2): 202-9, Feb. 1991.
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McGrail M et al. Peptide T studies: Neurophysiologic results. VII Ind Conf AIDS, Florence. Vol 1:194(M.B. 2049), 1991.
Mclntyre K et al. Pilot study of zidovudine (AZT) and zalcitabine (ddC) combination in HIV-associated dementia. Abstact #PBO 233, X Intl Conf AIDS, Yokohama, 1994.
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Price R et al. The brain in AIDS: Central nervous system HIV-1 infection and the AIDS dementia complex. Science 239: 586-92, 1988.
Price R et al. Central and peripheral nervous system complications of HIV-1 infecfion and AIDS. In: AIDS, Etiology, Diagnosis, Treatment and Prevention, eds. DeVita VT Hellman S and Rosenberg SA. J.B. Lippincott Company, Philadelphia, 3rd ed. 14:237-257, 1992.
Pullian L et al. Human immunodeficiency virus-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains. J Clin Invest 87(2): 503-12, Feb. 1991.
Satriano, J et al. Central nervous system stimulants as symptomatic treatment for AIDS dementia commplex. VII Intl Conf AIDS, Florence. Vol 1: 195 (M.B. 2053),1991.
Sidtis et al. Zidovudine treatment of the AIDS dementia complex: Results of a placebo-controlled trial. Ann Neur 1993.
Simpson DM et al. Neurologic Manifestations of HIV Infection. Ann Intem Med 121: 769-785,1994.
Stover E et al. CNS effects of HIV-1 infecfion and AIDS in infants and children: A collaborative research agenda. Ped AIDS and HIV Infection 1: 109-119, Nov. 6, 1990.
Wiley C et al. Human immunodeficiency virus: infection of the nervous system. Curr Topics Microbiol 160: 157-72, 1990.
Worley IM et al. Clinical manifestations of the HIV-1 infection of the nervous system. In: Handbook of Neurovirology, W Stroop and R McKendall, eds. Marcel Dekker, 1992.
Worley JM et al. Management of neurologic complications of HIV-1 infection. In: The Medical Mmagement of AIDS, M Sande md P Volberding, eds. Philadelphia: W.B. Saunders Co., third edition. 13:193-217,1992.
Tozzi V et al. Effects of zidovudine in 30 patients with mild to end-stage AIDS dementia complex. AIDS 7: 683-92, 1993.
OTHER REPORTS:
Aronow H et al. The management of the neurological complications of HIV infection and AIDS. AIDS 2(suppl 1): S 151-9, 1988.
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