HIV POSITIVE Treatment
Protease Inhibitors & You

Medications That Should Not Be Used With:

SAQUINAVIR (INVIRASE)
Drug Category Potential Alternatives
Antimycobacterial (Anti-TB or anti-MAC):
    rifampin (Rifadin, others)
 clarithromycin (Biaxin)
azithromycin (Zithromax)
ethambutol (Myambutol)
Cold and allergy antihistamines:
    astemizole (Hismanal),
    terfenadine (Seldane)
 loratadine (Claritin)
Gastrointestinal:
    cisapride (Propulsid)
 very limited clinical experience

INDINAVIR (CRIXIVAN), NELFINAVIR (VIRACEPT)
Drug Category Potential Alternatives
Antimycobacterial (Anti-TB or anti-MAC):
    rifampin (Rifadin, others)
 clarithromycin (Biaxin)
azithromycin (Zithromax)
ethambutol (Myambutol)
Cold and allergy antihistamines:
    astemizole (Hismanal),
    terfenadine (Seldane)
 loratadine (Claritin)
Gastrointestinal:
    cisapride (Propulsid)
 very limited clinical experience
Sedative/hypnotic midazolam (Versed)
triazolam (Halcion)

RITONAVIR (NORVIR)
Drug Category Potential Alternatives
Analgesic (pain reliever):
    meperidine (Demerol)
    piroxicam (Feldene)
    propoxyphene (Darvon, others)
 acetaminophen (Tylenol, others)
aspirin (Bayer, others)
oxycodone (Percocet, others)
Cardiovascular (for the heart):
    amiodarone (Cordarone)
    flecainide (Tambocor)
    propafenone (Rythmol)
    quinidine (various)
 very limited clinical experience
Antimycobacterial (Anti-TB or anti-MAC):
    rifabutin (Mycobutin)
 clarithromycin (Biaxin)
azithromycin (Zithromax)
ethambutol (Myambutol)
Calcium Channel Blocker (for the heart):
    bepridil (Vascor)
 very limited clinical experience
Ergot Alkaloid (vasoconstrictor):
    dihydroergotamine (D.H.E. 45)
    Ergotamine (various)
Cold and allergy antihistamines:
    astemizole (Hismanal),
    terfenadine (Seldane)
 loratadine (Claritin)
Gastrointestinal:
    cisapride (Propulsid)
 very limited clinical experience
Psychotropic (antidepressant):
    bupropion (Wellbutrin)
 fluoxetine (Prozac)
desipramine (Norpramin)
Psychotropic (neuroleptic):
    clozapine (Clozaril)
    pimozide (Orap)
 very limited clinical experience
Sedative/hypnotic:
    alprazolam (Xanax)
    clorazepate (Tranxene)
    diazepam (Valium)
    estazolam (ProSom)
    flurazepam (Dalmane)
    midazolam (Versed)
    triazolam (Halcion)
    zolpidem (Ambien)
 Temazepam (Restoril)
Lorazepam (Ativan)

* Please note that alternatives may not be therapeutically equivalent

References: Product Labeling
Invirase™ (December 6, 1995)
Norvir™ (March 1, 1996)
Drug Interactions: Physician Guide
Crixivan™ (March 13, 1996)

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