HIV Related Lipodystrophy

---

HIV realted lipodystrophy may be caused by protease inhibitors interfering with a liver protein that closely resembles a portion of the HIV protease gene. Since all protease inhibitors currently in use are structurally similar, they may all interfere with the proper function of this liver enzyme which helps control fat levels in the blood.

At the Fifth Conference on Retroviruses and Opportunistic Infections in Chicago, it was noted that protease inhibitor therapy appears to be associated with body changes in some patients.


The affects of lipodystrophy are numerous and still under evaluation:

• Elevated triglycerides, cholesterol and insulin levels
• The deterioration of a thin layer of fat directly beneath the skin
• Redistribution of fat
• Appearance of protruding veins
• Wasting of the face and limbs
• Accumulation of fat on the abdomen or between the shoulder blades.
• Women may also experience narrowing of the hips and enlargement of the breasts.

Some physicians conclude that while lipodystrophy is cosmetically undesirable and may cause significant psychological distress, it remains to be seen whether it is a symptom of a serious underlying condition.

Go to the Lipodystrophy Menu

Go to the Treatments for HIV/AIDS Menu

Go to the Treatment Menu

Go to the HIVpositive.com Main Menu