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Integrase Inhibitors
An oligonucleotide is a molecule comprised of many nucleoside units joined by 3'-5' phosphodiester linkages.
In essence, an oligonucleotide is a small segment of DNA or RNA, usually in the 10-35 base unit range. These are customarily prepared by solid phase synthesis on automated computer driven synthesizers.
Many molecular modifications have been incorporated in these synthetic oligonucleotides to enhance their binding to the desired target sequence of host DNA. These modified oligonucleotides also can serve to block RNA/DNA interactions and modify protein or enzyme synthesis. They have proven clinically useful in specific disease states.
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